5-Amino-1MQ

🔹 What is 5-Amino-1MQ?

• Class: Small molecule (not technically a peptide, but often grouped in biohacking circles).
• Mechanism: Inhibits nicotinamide N-methyltransferase (NNMT), which helps preserve intracellular NAD⁺ levels.
• Primary focus: Fat loss, metabolic support, improved mitochondrial efficiency, and potentially anti-aging applications.

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🔹 Oral Dosage (most common)

• Range studied/used in research: 50–150 mg per day
• Typical protocol:
  • 50 mg 2–3x daily with meals.
  • Split dosing helps maintain steady exposure due to limited half-life.
• Notes: Oral bioavailability is decent, making this the most common route.

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🔹 Injectable Dosage (subcutaneous or IM – less common)

• Range: 5–10 mg daily (occasionally up to 15 mg/day in experimental settings).
  • Recommend titrating up from 1mg daily to determine your tolerance and any side effects. Increase dosage as needed.
• Frequency: Once daily or every other day, depending on goal and tolerance.
• Rationale: Lower doses are used vs oral due to bypassing first-pass metabolism.

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🔹 Cycle Length

• Common cycle length: 4–8 weeks
• Off-cycle: At least 2–4 weeks off before restarting, to prevent desensitization or adaptation.
• Many stackers will run it alongside metabolic agents like AOD-9604, Tesofensine, or GLP-1 agonists in fat-loss protocols.

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🔹 Optimal Dosing Window

• Oral:
  • Morning dose (fasted or with light meal)
  • Midday dose (to sustain NAD⁺/energy)
  • Optional early afternoon dose (avoid evening if sleep disruption occurs).
• Injectable:
  • Once daily, typically morning or pre-workout for metabolic boost.

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✅ Educational Integration Example (oral):

• 50 mg at 8 AM, 50 mg at 1 PM, 50 mg at 5 PM.
• Run for 6 weeks, then take 2–4 weeks off.

✅ Educational Integration Example (injectable):

• 10 mg subQ each morning for 5 weeks.
• Pair with caloric deficit and mitochondrial support supplements (e.g., NMN, resveratrol).

🔹 Stacking Strategy (Educational)

Since 5-Amino-1MQ works by preserving NAD⁺ and enhancing metabolism, stacks should complement this:

🔸 Fat Loss Synergy

• AOD-9604 – enhances lipolysis, synergizes for adipose targeting.
• Tesofensine or GLP-1 agonists (semaglutide, liraglutide) – appetite control + metabolic rate support.
• GH fragments (CJC-1295/Ipamorelin) – improve fat loss & muscle retention.

🔸 NAD⁺ / Mitochondrial Support

• NMN or NR – additional NAD⁺ precursors, amplified by NNMT inhibition.
• Resveratrol or Pterostilbene – sirtuin activators to leverage NAD⁺ gains.
• Methylene Blue (low-dose) – mitochondrial redox enhancer.

🔸 Anti-Aging / Energy Stack

• 5-Amino-1MQ + NAD⁺ precursor (NMN/NR) + sirtuin activator (resveratrol)
• Optional add-on: MOTS-c (mitochondrial peptide) for synergistic endurance and metabolic health.

Disclaimer: Do not rely on any dosing information provided, this is for educational and research only. Always double and triple check alternative references for education. Please consult with healthcare provider for your specific dosing and protocol if applicable.