SS-31 (Elamipretide) · Pastor Peptide

🔹 What is SS-31?

Class: Synthetic mitochondria-targeted tetrapeptide; also known as Elamipretide, MTP-131, and Bendavia. Mechanism:

Binds to cardiolipin, a phospholipid in the inner mitochondrial membrane, stabilizing its structure.
Enhances electron transfer in the mitochondrial respiratory chain, reducing reactive oxygen species (ROS) production.
Prevents mitochondrial permeability transition pore (mPTP) formation, preserving mitochondrial integrity.
Improves mitochondrial membrane potential, ATP production, and biogenesis.
Exhibits antioxidant and anti-inflammatory properties, mitigating oxidative stress and inflammation.

Primary focus:

Mitochondrial dysfunction and related diseases.
Age-related decline in mitochondrial function.
Neurological disorders (e.g., Alzheimer’s, Parkinson’s).
Cardiovascular diseases (e.g., heart failure).
Metabolic disorders (e.g., diabetes, obesity).
Musculoskeletal diseases (e.g., mitochondrial myopathy).

🔹 Oral Dosage

Not applicable; SS-31 has poor oral bioavailability and requires parenteral administration.

🔹 Injectable / Subcutaneous Dosage (most common) Range:

0.5–2 mg/kg body weight, administered subcutaneously or intravenously.
Frequency: Typically once daily or as directed by clinical protocols.

Rationale: Direct administration ensures effective delivery to mitochondria, bypassing absorption barriers.

🔹 Cycle Length

Acute applications: Single-dose or short-term treatment.
Chronic applications: Cycles ranging from 4 to 12 weeks, depending on the condition being treated.

🔹 Optimal Dosing Window

Administered at any time of day, based on clinical protocol.
For acute conditions, dosing may be more frequent, while chronic conditions may require less frequent dosing.

✅ Educational Integration Example Example protocol: 1 mg/kg SS-31 subcutaneously daily for 6 weeks. Paired with: CoQ10, PQQ, and L-Carnitine for enhanced mitochondrial support. Rationale: Combines SS-31’s mitochondrial stabilization with other agents to optimize energy production and reduce oxidative stress.

🔹 Stacking Strategy (Educational / Complementary) Since SS-31 primarily targets mitochondrial function, stacking strategies focus on enhancing mitochondrial health, antioxidant defense, and cellular energy production: 🔸 Mitochondrial & Energy Support

CoQ10: Supports the electron transport chain and ATP synthesis.
PQQ: Promotes mitochondrial biogenesis and function.
L-Carnitine: Facilitates fatty acid transport into mitochondria for energy production.

🔸 Antioxidant & Anti-inflammatory Support

NAC (N-Acetyl Cysteine): Precursor to glutathione, a major antioxidant.
Curcumin: Exhibits anti-inflammatory and antioxidant properties.
Omega-3 fatty acids: Reduce inflammation and support mitochondrial function.

Rationale: Combining SS-31 with complementary agents can enhance mitochondrial function, reduce oxidative stress, and support overall cellular health.

⚠️ Safety Notes

Gastrointestinal side effects (e.g., nausea, diarrhea) may occur, especially during dose escalation.
Monitor for signs of hypoglycemia, particularly in patients with type 2 diabetes.
Contraindicated in patients with a history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2.
Not intended for human or animal use; for research purposes only.

Studied in Humans? Yes

FDA Approved? No

Allowed for 503a Compounding Pharmacy? No

Disclaimer: Do not rely on any dosing information provided, this is for educational and research only. Always double and triple check alternative references for education. Please consult with healthcare provider for your specific dosing and protocol if applicable.